Repetitive Transcranial Magnetic Stimulation as an Add-On Treatment for Cognitive Impairment in Alzheimer’s Disease and Its Impact on Self-Rated Quality of Life and Caregiver’s Burden - Université de Franche-Comté Accéder directement au contenu
Article Dans Une Revue Brain Sciences Année : 2021

Repetitive Transcranial Magnetic Stimulation as an Add-On Treatment for Cognitive Impairment in Alzheimer’s Disease and Its Impact on Self-Rated Quality of Life and Caregiver’s Burden

Juliana Teti Mayer
Caroline Masse
  • Fonction : Auteur
Gilles Chopard
  • Fonction : Auteur
Magali Nicolier
Matthieu Bereau
  • Fonction : Auteur
Eloi Magnin
Julie Monnin
Gregory Tio
  • Fonction : Auteur
Emmanuel Haffen
Pierre Vandel
  • Fonction : Auteur
  • PersonId : 910812
Djamila Bennabi
  • Fonction : Auteur

Résumé

Alzheimer’s disease (AD) is associated with progressive memory loss and decline in executive functions, as well as neuropsychiatric symptoms. Patients usually consider quality of life (QoL) and mood as more important for their health status than disease-specific physical and mental symptoms. In this open-label uncontrolled trial, 12 subjects diagnosed with AD underwent 10 sessions of repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex (10 Hz, 20 min, 2000 pulses/day, 110% MT). Outcomes were measured before and 30 days after treatment. Our primary objective was to test the efficacy of rTMS as an add-on treatment for AD on the global cognitive function, assessed through the Mini-Mental State Examination (MMSE) and the Mattis Dementia Rating Scale (MDRS). As secondary objectives, the detailed effect on cognitive functions, depression and anxiety symptoms, QoL, and functionality in daily life activities were evaluated, as well as correlations between QoL and cognition, depression and anxiety scores. The treatment significantly enhanced semantic memory and reduced anxiety. Improvement of these features in AD could become an important target for treatment strategies. Although limited by its design, this trial may contribute with another perspective on the analysis and the impact of rTMS on AD.

Dates et versions

hal-03656175 , version 1 (01-05-2022)

Identifiants

Citer

Juliana Teti Mayer, Caroline Masse, Gilles Chopard, Magali Nicolier, Matthieu Bereau, et al.. Repetitive Transcranial Magnetic Stimulation as an Add-On Treatment for Cognitive Impairment in Alzheimer’s Disease and Its Impact on Self-Rated Quality of Life and Caregiver’s Burden. Brain Sciences, 2021, 11 (6), pp.740. ⟨10.3390/brainsci11060740⟩. ⟨hal-03656175⟩

Collections

UNIV-FCOMTE
13 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More