Article Dans Une Revue Pathogens Année : 2022

Antimicrobial resistance in enterobacterales recovered from urinary tract infections in France

Eric Farfour
Laurent Dortet
Thomas Guillard
Nicolas Chatelain
  • Fonction : Auteur
Agathe Poisson
  • Fonction : Auteur
Assaf Mizrahi
  • Fonction : Auteur
Rémy Bonnin
Nicolas Degand
Philippe Morand
  • Fonction : Auteur
Frédéric Janvier
  • Fonction : Auteur
Vincent Fihman
Stéphane Corvec
Lauranne Broutin
  • Fonction : Auteur
Cécile Le Brun
Nicolas Yin
  • Fonction : Auteur
Geneviève Héry-Arnaud
Antoine Grillon
  • Fonction : Auteur
Emmanuelle Bille
Hélène Jean-Pierre
  • Fonction : Auteur
Marlène Amara
  • Fonction : Auteur
Francoise Jaureguy
  • Fonction : Auteur
Christophe Isnard
  • Fonction : Auteur
Vincent Cattoir
Tristan Diedrich
Emilie Flevin
  • Fonction : Auteur
Audrey Merens
  • Fonction : Auteur
Hervé Jacquier
  • Fonction : Auteur
Marc Vasse

Résumé

In the context of increasing antimicrobial resistance in Enterobacterales, the management of these UTIs has become challenging. We retrospectively assess the prevalence of antimicrobial resistance in Enterobacterales isolates recovered from urinary tract samples in France, between 1 September 2017, to 31 August 2018. Twenty-six French clinical laboratories provided the susceptibility of 134,162 Enterobacterales isolates to 17 antimicrobials. The most frequent species were $E.\ coli$ (72.0%), $Klebsiella\ pneumoniae$ (9.7%), $Proteus\ mirabilis$ (5.8%), and $Enterobacter\ cloacae$ complex (2.9%). The overall rate of ESBL-producing Enterobacterales was 6.7%, and ranged from 1.0% in $P.\ mirabilis$ to 19.5% in $K.\ pneumoniae$, and from 3.1% in outpatients to 13.6% in long-term care facilities. Overall, 4.1%, 9.3% and 10.5% of the isolates were resistant to cefoxitin, temocillin and pivmecillinam. Cotrimoxazole was the less active compound with 23.4% resistance. Conversely, 4.4%, 12.9%, and 14.3% of the strains were resistant to fosfomycin, nitrofurantoin, and ciprofloxacin. However, less than 1% of E. coli was resistant to fosfomycin and nitrofurantoin. We identified several trends in antibiotics resistances among Enterobacterales isolates recovered from the urinary tract samples in France. Carbapenem-sparing drugs, such as temocillin, mecillinam, fosfomycin, cefoxitin, and nitrofurantoin, remained highly active, including towards ESBL-E.
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hal-04225877 , version 1 (17-01-2024)

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Eric Farfour, Laurent Dortet, Thomas Guillard, Nicolas Chatelain, Agathe Poisson, et al.. Antimicrobial resistance in enterobacterales recovered from urinary tract infections in France. Pathogens, 2022, 11 (3), pp.356. ⟨10.3390/pathogens11030356⟩. ⟨hal-04225877⟩

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