Cefiderocol activity is compromised by acquired extended-spectrum oxacillinases in Pseudomonas aeruginosa - Université de Franche-Comté Accéder directement au contenu
Article Dans Une Revue International Journal of Antimicrobial Agents Année : 2023

Cefiderocol activity is compromised by acquired extended-spectrum oxacillinases in Pseudomonas aeruginosa

Résumé

Cefiderocol has an excellent in vitro activity on clinical strains of Pseudomonas aeruginosa (P. aeruginosa). However, the resistance of some isolates has been associated with the production of some β-lactamases. Whether some acquired extended-spectrum oxacillinases (ES-OXA) common in this species may compromise the susceptibility of P. aeruginosa to cefiderocol has not been evaluated so far.
Eighteen genes encoding OXA belonging to the major subgroups identified in P. aeruginosa OXA-1 (n = 3); - 2 (n = 5); - 10 (n = 8), and - 46 (n = 2) were cloned into pUCP24 shuttle vector and transferred into reference strain PAO1.
Fichier non déposé

Dates et versions

hal-04225762 , version 1 (03-10-2023)

Identifiants

Citer

Xavier Vuillemin, Maëlle da Silva, Maxime Bour, Céline Landon, Patrick Plésiat, et al.. Cefiderocol activity is compromised by acquired extended-spectrum oxacillinases in Pseudomonas aeruginosa. International Journal of Antimicrobial Agents, 2023, 62 (3), pp.106917. ⟨10.1016/j.ijantimicag.2023.106917⟩. ⟨hal-04225762⟩
31 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More