Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer’s Disease Therapy - Archive ouverte HAL Access content directly
Journal Articles Molecules Year : 2020

Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer’s Disease Therapy

Lazhar Zribi
  • Function : Author
Irene Pachòn-Angona
  • Function : Author
Òscar Bautista-Aguilera
Daniel Diez-Iriepa
  • Function : Author
José Marco-Contelles
Isabel Iriepa
Fakher Chabchoub

Abstract

Alzheimer’s disease (AD) is multifactorial disease characterized by the accumulation of abnormal extracellular deposits of amyloid-beta (Aβ) peptide, and intracellular neurofibrillary tangles (NFTs), along with dramatic neuronal death and decreased levels of choline acetyltransferase. Given the limited therapeutic success of available drugs, it is urgent to explore all the opportunities available to combat this illness. Among them, the discovery of new heterocyclic scaffolds binding different receptors involved in AD should offer structural diversity and new therapeutic solutions. In this context, this work describes new triazolopyridopyrimidine easily prepared in good yields showing anticholinesterase inhibition and strong antioxidant power, particularly the most balanced: 6-amino-5-(4-methoxyphenyl)-2-phenyl-[1,2,4]triazolo[1′,5′:1,6] pyrido[2,3-d]pyrimidine-4-carbonitrile(3c) with IC50 equal to 1.32 μM against AChE and oxygen radical absorbance capacity (ORAC) value equal to 4.01 Trolox equivalents (TE); thus representing a new and very promising hit-triazolopyridopyrimidine for AD therapy.

Dates and versions

hal-03654594 , version 1 (28-04-2022)

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Lazhar Zribi, Irene Pachòn-Angona, Òscar Bautista-Aguilera, Daniel Diez-Iriepa, José Marco-Contelles, et al.. Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer’s Disease Therapy. Molecules, 2020, 25 (14), pp.3190. ⟨10.3390/molecules25143190⟩. ⟨hal-03654594⟩

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