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Article Dans Une Revue Molecules Année : 2020

Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer’s Disease Therapy

Lazhar Zribi
  • Fonction : Auteur
Irene Pachòn-Angona
  • Fonction : Auteur
Òscar Bautista-Aguilera
Daniel Diez-Iriepa
  • Fonction : Auteur
José Marco-Contelles
Isabel Iriepa
Fakher Chabchoub

Résumé

Alzheimer’s disease (AD) is multifactorial disease characterized by the accumulation of abnormal extracellular deposits of amyloid-beta (Aβ) peptide, and intracellular neurofibrillary tangles (NFTs), along with dramatic neuronal death and decreased levels of choline acetyltransferase. Given the limited therapeutic success of available drugs, it is urgent to explore all the opportunities available to combat this illness. Among them, the discovery of new heterocyclic scaffolds binding different receptors involved in AD should offer structural diversity and new therapeutic solutions. In this context, this work describes new triazolopyridopyrimidine easily prepared in good yields showing anticholinesterase inhibition and strong antioxidant power, particularly the most balanced: 6-amino-5-(4-methoxyphenyl)-2-phenyl-[1,2,4]triazolo[1′,5′:1,6] pyrido[2,3-d]pyrimidine-4-carbonitrile(3c) with IC50 equal to 1.32 μM against AChE and oxygen radical absorbance capacity (ORAC) value equal to 4.01 Trolox equivalents (TE); thus representing a new and very promising hit-triazolopyridopyrimidine for AD therapy.

Dates et versions

hal-03654594 , version 1 (28-04-2022)

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Citer

Lazhar Zribi, Irene Pachòn-Angona, Òscar Bautista-Aguilera, Daniel Diez-Iriepa, José Marco-Contelles, et al.. Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer’s Disease Therapy. Molecules, 2020, 25 (14), pp.3190. ⟨10.3390/molecules25143190⟩. ⟨hal-03654594⟩

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