Transcranial direct current stimulation for acute major depressive episodes: Meta-analysis of individual patient data - Université de Franche-Comté Accéder directement au contenu
Article Dans Une Revue British Journal of Psychiatry Année : 2016

Transcranial direct current stimulation for acute major depressive episodes: Meta-analysis of individual patient data

Résumé

Background Transcranial direct current stimulation (tDCS) is a non-pharmacological intervention for depression. It has mixed results, possibly caused by study heterogeneity. Aims To assess tDCS efficacy and to explore individual response predictors. Method Systematic review and individual patient data meta-analysis. Results Data were gathered from six randomised sham-controlled trials, enrolling 289 patients. Active tDCS was significantly superior to sham for response (34% v. 19% respectively, odds ratio (OR) = 2.44, 95% CI 1.38–4.32, number needed to treat (NNT) = 7), remission (23.1% v. 12.7% respectively, OR = 2.38, 95% CI 1.22–4.64, NNT = 9) and depression improvement ( B coefficient 0.35, 95% CI 0.12–0.57). Mixed-effects models showed that, after adjustment for other predictors and confounders, treatment-resistant depression and higher tDCS ‘doses' were, respectively, negatively and positively associated with tDCS efficacy. Conclusions The effect size of tDCS treatment was comparable with those reported for repetitive transcranial magnetic stimulation and antidepressant drug treatment in primary care. The most important parameters for optimisation in future trials are depression refractoriness and tDCS dose.

Dates et versions

hal-03655697 , version 1 (29-04-2022)

Identifiants

Citer

André Brunoni, Adriano Moffa, Felipe Fregni, Ulrich Palm, Frank Padberg, et al.. Transcranial direct current stimulation for acute major depressive episodes: Meta-analysis of individual patient data. British Journal of Psychiatry, 2016, 208 (6), pp.522-531. ⟨10.1192/bjp.bp.115.164715⟩. ⟨hal-03655697⟩

Collections

UNIV-FCOMTE
13 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More