Association of Amyotrophic Lateral Sclerosis and Alzheimer’s Disease: New Entity or Coincidence? A Case Series - Archive ouverte HAL Access content directly
Journal Articles Journal of Alzheimer's Disease Year : 2021

Association of Amyotrophic Lateral Sclerosis and Alzheimer’s Disease: New Entity or Coincidence? A Case Series

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Agathe Vrillon
  • Function : Author
Vincent Deramecourt
  • Function : Author
Florence Pasquier
  • Function : Author
David Wallon
  • Function : Author
Pierre Lozeron
  • Function : Author
Élodie Bouaziz-Amar
  • Function : Author
Claire Paquet
  • Function : Author

Abstract

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia have a strong clinical, genetic, and pathological connection but association of ALS with Alzheimer’s disease (AD) is seldom reported. We report a series of 5 cases of AD associated with ALS. Our patients presented with cognitive deterioration with episodic memory impairment meeting criteria for AD. ALS occurred subsequently in all cases and its phenotype was not homogenous. Amyloid process was confirmed in four cases with cerebrospinal fluid biomarkers. One case underwent postmortem exam, demonstrating hallmarks lesions of both diseases. This series highlights that ALS-AD phenotype could be a specific underexplored entity.
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hal-03630021 , version 1 (04-04-2022)

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Agathe Vrillon, Vincent Deramecourt, Florence Pasquier, Éloi Magnin, David Wallon, et al.. Association of Amyotrophic Lateral Sclerosis and Alzheimer’s Disease: New Entity or Coincidence? A Case Series. Journal of Alzheimer's Disease, 2021, 84 (4), pp.1439-1446. ⟨10.3233/JAD-215226⟩. ⟨hal-03630021⟩

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